AS 604850 | 2339

Cell-permeable. A selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS 604850 inhibits MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduces RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.

As 604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC₅₀ values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively.

2339 | AS 604850 DataSheet

Alternate Name/Synonyms: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

Appearance: Off-white solid

Formulation: N/A

CAS Number: 648449-76-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₁H₅F₂NO₄S

Molecular Weight: 285.22

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (50 mg/ml) or Ethanol (5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A selective, ATP-competitive inhibitor of PI3Kγ

MDL Number: MFCD19705528

PubChem CID: 5287855

SMILES: C1=CC2=C(C=C1C=C3C(=O)NC(=O)S3)OC(O2)(F)F

InChi: InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-

InChi Key: SRLVNYDXMUGOFI-YWEYNIOJSA-N