Description
Cell-permeable. A selective, ATP-competitive inhibitor of PI3Kγ with IC50 values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS 604850 inhibits MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduces RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg.
As 604850 is a selective, ATP-competitive inhibitor of PI3Kγ with IC₅₀ values of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively.
Alternate Name/Synonyms: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Appearance: Off-white solid
Formulation: N/A
CAS Number: 648449-76-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₁H₅F₂NO₄S
Molecular Weight: 285.22
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (50 mg/ml) or Ethanol (5 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A selective, ATP-competitive inhibitor of PI3Kγ
MDL Number: MFCD19705528
PubChem CID: 5287855
SMILES: C1=CC2=C(C=C1C=C3C(=O)NC(=O)S3)OC(O2)(F)F
InChi: InChI=1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-
InChi Key: SRLVNYDXMUGOFI-YWEYNIOJSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |