AS601245 | 2162

Cell-permeable. AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.

AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.

2162 | AS601245 DataSheet

Alternate Name/Synonyms: (Z)-2-(Benzo[d]thiazol-2(3H)-ylidene)-2-(2-((-(pyridine-3-yl)ethyl)amino)pyridine-4-yl)acetonitrile

Appearance: White to yellow solid

Formulation: N/A

CAS Number: 345987-15-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₆N₆S

Molecular Weight: 372.45

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: An ATP-competitive JNK inhibitor

MDL Number: MFCD07772196

PubChem CID: 11422035

SMILES: C1=CC=C2C(=C1)NC(=C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4)S2

InChi: InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+

InChi Key: AVLYNJZZQYEFEA-XDJHFCHBSA-N