Description
Cell-permeable. AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
AS601245 is a potent, ATP-competitive JNK inhibitor (hJNK1: IC₅₀ = 150 nM, hJNK2: IC₅₀ = 220 nM and hJNK3: IC₅₀ = 70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.
Alternate Name/Synonyms: (Z)-2-(Benzo[d]thiazol-2(3H)-ylidene)-2-(2-((-(pyridine-3-yl)ethyl)amino)pyridine-4-yl)acetonitrile
Appearance: White to yellow solid
Formulation: N/A
CAS Number: 345987-15-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₁₆N₆S
Molecular Weight: 372.45
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (10 mg/ml)
Handling: Protect from light and mositure
Country of Origin: USA
Tag Line: An ATP-competitive JNK inhibitor
MDL Number: MFCD07772196
PubChem CID: 11422035
SMILES: C1=CC=C2C(=C1)NC(=C(C#N)C3=NC(=NC=C3)NCCC4=CN=CC=C4)S2
InChi: InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,25H,7,10H2,(H,23,24,26)/b19-15+
InChi Key: AVLYNJZZQYEFEA-XDJHFCHBSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |