ASP7663 | B2976

ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It releases 5-HT from QGP-1 cells. It enhances colonic motility and exerts anti-constipation, analgesic effects against abdominal pain in vivo.

ASP7663 is a selective transient receptor potential ankyrin 1 (TRPA1) activator. It activates human, rat and mouse TRPA1 receptors with EC₅₀ values of 510 nM, 540 nM and 500 nM, respectively. It releases 5-HT from QGP-1 cells. It enhances colonic motility and exerts anti-constipation, analgesic effects against abdominal pain in vivo.

B2976 | ASP7663 DataSheet

Alternate Name/Synonyms: (2E)-2-[7-fluoro-1-(2-methylpropyl)-2-oxoindol-3-ylidene]acetic acid; (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid; (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid

Appearance: Solid

Formulation:

CAS Number: 1190217-35-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₄H₁₄FNO₃

Molecular Weight: 263.26

Cell-Permeable?: False

Purity: 98%

Solubilities: ~25 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective TRPA1 activator

MDL Number:

PubChem CID: 44232532

SMILES: CC(C)CN1C2=C(C=CC=C2F)C(=CC(=O)O)C1=O

InChi: InChI=1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+

InChi Key: RCVZUIGCNAAMIC-UXBLZVDNSA-N