Ataciguat | B2574

Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of soluble guanylate cyclase (sGC) (EC₅₀= 0.5-10 µM in purified bovine lung or crude human corpus cavernosum isolates) by binding to the heme pocket and mimicking its function. It has been shown to increase cGMP levels in cultured rat aorta smooth muscle cells and to induce vasorelaxation of isolated rat aorta, porcine coronary arteries, and human corpus cavernosum (EC₅₀ = 1-10 µM).

Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of soluble guanylate cyclase (sGC) (EC₅₀= 0.5-10 µM in purified bovine lung or crude human corpus cavernosum isolates) by binding to the heme pocket and mimicking its function. It has been shown to increase cGMP levels in cultured rat aorta smooth muscle cells and to induce vasorelaxation of isolated rat aorta, porcine coronary arteries, and human corpus cavernosum (EC₅₀ = 1-10 µM).

B2574 | Ataciguat DataSheet

Alternate Name/Synonyms: HMR-1766, 5-Chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide

Appearance: White to pale yellow solid

Formulation:

CAS Number: 254877-67-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₉Cl₂N₃O₆S₃

Molecular Weight: 576.5

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~ 1 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A sGC activator

MDL Number: MFCD09837865

PubChem CID: 213037

SMILES: C1COCCN1S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=CC(=C3)Cl)NS(=O)(=O)C4=CC=C(S4)Cl

InChi: InChI=1S/C21H19Cl2N3O6S3/c22-14-1-6-18(25-34(28,29)20-8-7-19(23)33-20)17(13-14)21(27)24-15-2-4-16(5-3-15)35(30,31)26-9-11-32-12-10-26/h1-8,13,25H,9-12H2,(H,24,27)

InChi Key: PQHLRGARXNPFCF-UHFFFAOYSA-N