Description
Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of soluble guanylate cyclase (sGC) (EC₅₀= 0.5-10 µM in purified bovine lung or crude human corpus cavernosum isolates) by binding to the heme pocket and mimicking its function. It has been shown to increase cGMP levels in cultured rat aorta smooth muscle cells and to induce vasorelaxation of isolated rat aorta, porcine coronary arteries, and human corpus cavernosum (EC₅₀ = 1-10 µM).
Ataciguat is an anthranilic acid derivative that activates the oxidized (heme-free) form of soluble guanylate cyclase (sGC) (EC₅₀= 0.5-10 µM in purified bovine lung or crude human corpus cavernosum isolates) by binding to the heme pocket and mimicking its function. It has been shown to increase cGMP levels in cultured rat aorta smooth muscle cells and to induce vasorelaxation of isolated rat aorta, porcine coronary arteries, and human corpus cavernosum (EC₅₀ = 1-10 µM).
Alternate Name/Synonyms: HMR-1766, 5-Chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide
Appearance: White to pale yellow solid
Formulation:
CAS Number: 254877-67-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₁₉Cl₂N₃O₆S₃
Molecular Weight: 576.5
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: ~ 1 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A sGC activator
MDL Number: MFCD09837865
PubChem CID: 213037
SMILES: C1COCCN1S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=CC(=C3)Cl)NS(=O)(=O)C4=CC=C(S4)Cl
InChi: InChI=1S/C21H19Cl2N3O6S3/c22-14-1-6-18(25-34(28,29)20-8-7-19(23)33-20)17(13-14)21(27)24-15-2-4-16(5-3-15)35(30,31)26-9-11-32-12-10-26/h1-8,13,25H,9-12H2,(H,24,27)
InChi Key: PQHLRGARXNPFCF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |