ATM Rabbit monoclonal Antibody | BS9893M

ATM Rabbit monoclonal Antibody | BS9893M | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC

Application Range: WB: 1:1000-1:5000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200

Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of ATM and does not cross-react with related proteins.

Molecular Weight: ~ 370 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated; ATM

Immunogen: Recombinant Antibody.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified

Pathway: