BW
ATM Rabbit monoclonal Antibody | BS9893M
- SKU:
- BW-BS9893M
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- Usually ships in 5 working days
Description
ATM Rabbit monoclonal Antibody | BS9893M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human
Application: WB ICC/IF IHC
Application Range: WB: 1:1000-1:5000 ICC/IF: 1:50-1:200 IHC: 1:50-1:200
Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of ATM and does not cross-react with related proteins.
Molecular Weight: ~ 370 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated; ATM
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: