ATP-Citrate synthase (P449) polyclonal Antibody | BS1715

ATP-Citrate synthase (P449) polyclonal Antibody | BS1715 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:1000 IF: 1:50~1:200

Background: ATP citrate lyase (ACL) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer of four identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. One of these products, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. NDPK has been found to phosphorylate ACL and insulin to increase phosphorylation of ACL.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ATP-citrate synthase (P449) polyclonal Antibody detects endogenous levels of ATP-citrate synthase protein.

Molecular Weight: ~ 120 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ATP-citrate synthase; ATP-citrate (pro-S-) -lyase; ACL; Citrate cleavage enzyme; ACLY

Immunogen: Synthetic peptide, corresponding to amino acids 430-480 of Human ATP-Citrate synthase.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A