AUDA | B3371

AUDA | B3371

Description: AUDA is an inhibitor of soluble epoxide hydrolase (sEH) (displaying IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. Produces a hypotensive effect in angiotensin-infused rats and prevents and reverses cardiac hypertrophy in mouse models of cardiac hypertrophy. AUDA activates peroxisome proliferator-activated receptor α (PPARα) 3-fold at a concentration of 10 µM but exhibits no effect on PPARδ or PPARγ.

Alternate Name/Synonyms: 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

Appearance: Solid

Formulation:

CAS Number: 479413-70-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₄₀N₂O₃

Molecular Weight: 392.6

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~1 mg/ml DMSO

Handling: Do not tr gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A soluble epoxide hydrolase (sEH) inhibitor

MDL Number:

PubChem CID: 10069117

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/10069117

SMILES: C1C2CC3CC1CC(C2)(C3)NC(=O)NCCCCCCCCCCCC(=O)O

InChi: InChI=1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28)

InChi Key: XLGSEOAVLVTJDH-UHFFFAOYSA-N

Category: Biochemicals