Description
An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Auranofin is an anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Alternate Name/Synonyms: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate; SKF39162
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 34031-32-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₃₄AuO₉PS
Molecular Weight: 678.48
Cell-Permeable?: Yes
Purity: ≥98% by NMR
Solubilities: DMSO (100 mM) or Ethanol (50 mM)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: Leukocyte activation pathways inhibitor
MDL Number: MFCD00080759
PubChem CID: 24199313
SMILES: CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
InChi: InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1
InChi Key: AUJRCFUBUPVWSZ-UHFFFAOYSA-M
Additional Information
Storage Condition: |
RT |
Shipping Condition: |
RT |
Shelf Life: |
24 months |