Aurora-B Antibody (Aurkb)| F44415-0.08ML

Aurora-B Antibody (Aurkb)| F44415-0.08ML | Gentaur UK, US & Europe Distribution

Background: Aurkb may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. Required for kinetochore localization of BUB1 and SGOL1 (By similarity).

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Rat

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the Aurkb antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Aurkb antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 84-111 from the mouse protein was used as the immunogen for this Aurkb antibody.

Storage: Aliquot the Aurkb antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A