26
Aurora Kinase B Inhibitor (AZD1152-HQPA) | 1583
- SKU:
- 26-1583-GEN
- Availability:
- Usually shipped in 5 working days
Description
A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively). At concentrations as low as 0.01 µM, AZD 1152 produced a significant (p<0.05) decrease in the ability of NB4 cells to proliferate by 48 hours.
Aurora Kinase B Inhibitor (AZD1152-HQPA) is a potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively).
1583 | Aurora Kinase B Inhibitor (AZD1152-HQPA) DataSheet
Alternate Name/Synonyms: AZD1152-HQPA
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 722544-51-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₃₀FN₇O₃
Molecular Weight: 507.56
Cell-Permeable?: Yes
Purity: ≥99% by HPLC
Solubilities: DMSO
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: An Aurora kinase B inhibitor
MDL Number: MFCD10687152
PubChem CID: 16007391
SMILES: CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
InChi: InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28- 17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3, 5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChi Key: QYZOGCMHVIGURT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
RT |
Shelf Life: |
24months |