Autophinib | B2260

Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.

B2260 | Autophinib DataSheet

Alternate Name/Synonyms: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine

Appearance: White solid

Formulation: N/A

CAS Number: 1644443-47-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₁ClN₆O₃

Molecular Weight: 346.73

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>6 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent autophagy inhibitor

MDL Number: N/A

PubChem CID: 129626605

SMILES: CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl

InChi: InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)

InChi Key: CEUMAXLRGBKFQP-UHFFFAOYSA-N