Description
Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.
Autophinib is a potent autophagy inhibitor. It inhibits autophagy induced by starvation or rapamycin by targeting the lipid kinase VPS34 with IC50s of 90, 40 and 19 nM, respectively.
Alternate Name/Synonyms: 6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)-pyrimidinamine
Appearance: White solid
Formulation: N/A
CAS Number: 1644443-47-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₁ClN₆O₃
Molecular Weight: 346.73
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>6 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent autophagy inhibitor
MDL Number: N/A
PubChem CID: 129626605
SMILES: CC1=CC(=NN1)NC2=CC(=NC(=N2)OC3=CC=C(C=C3)[N+](=O)[O-])Cl
InChi: InChI=1S/C14H11ClN6O3/c1-8-6-13(20-19-8)17-12-7-11(15)16-14(18-12)24-10-4-2-9(3-5-10)21(22)23/h2-7H,1H3,(H2,16,17,18,19,20)
InChi Key: CEUMAXLRGBKFQP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |