Description
AVL-292 is a potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK) (IC₅₀ = 0. 5 nM) with potential antineoplastic activity.
AVL-292 is a potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK) (IC₅₀ = 0. 5 nM) with potential antineoplastic activity.
9413 | AVL-292 (Spebrutinib) DataSheet
Alternate Name/Synonyms: N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide; CC-292
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 1202757-89-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₂H₂₂FN₅O₃
Molecular Weight: 423.44
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, selective inhibitor of Bruton’s Tyrosine Kinase (BTK)
MDL Number: N/A
PubChem CID: 59174488
SMILES: COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F
InChi: InChI=1S/C22H22FN5O3/c1-3-20(29)25-16-5-4-6-17(13-16)26-21-19(23)14-24-22(28-21)27-15-7-9-18(10-8-15)31-12-11-30-2/h3-10,13-14H,1,11-12H2,2H3,(H,25,29)(H2,24,26,27,28)
InChi Key: KXBDTLQSDKGAEB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |