Axitinib (AG-013736) | 1581

Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117). It has been shown to significantly inhibit growth of breast cancer in xenograft models and renal cell carcinoma (RCC) and several other tumor types.

Axitinib (also known as AG-013736) is a small molecule tyrosine kinase inhibitor. It inhibits multiple targets, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, and cKIT (CD117).

1581 | Axitinib (AG-013736) DataSheet

Alternate Name/Synonyms: AG-013736

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 319460-85-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₈N₄OS

Molecular Weight: 386.47

Cell-Permeable?: Yes

Purity: ≥99% by HPLC

Solubilities: DMSO (10 mM)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A PTK inhibitor

MDL Number: MFCD09837898

PubChem CID: 6450551

SMILES: CNC(=O)C1=CC=CC=C1SC2=CC3=C(C=C2)C(=NN3)C=CC4=CC=CC=N4

InChi: InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25- 26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25, 26)/b12-9+

InChi Key: RITAVMQDGBJQJZ-FMIVXFBMSA-N