AZD-2461 | B3103

AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development of drug resistance.

AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development of drug resistance.

B3103 | AZD-2461 DataSheet

Alternate Name/Synonyms: 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one; 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Appearance: White to beige powder

Formulation:

CAS Number: 1174043-16-3

Structure Available?: Yes

Peptide sequence:

Salt Form: No

Molecular Formula: C₂₂H₂₂FN₃O₃

Molecular Weight: 395.43

Cell-Permeable?: True

Purity: ≥ 98%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of PARP

MDL Number: MFCD24386811

PubChem CID: 44199317

SMILES: COC1CCN(CC1)C(=O)C2=C(C=CC(=C2)CC3=NNC(=O)C4=CC=CC=C43)F

InChi: InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)

InChi Key: HYNBNUYQTQIHJK-UHFFFAOYSA-N