AZD-5153 | B2020

AZD-5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with a bivalent binding mode. AZD-5153 ligates two bromodomains in BRD4 simultaneously. Displays cellular and antitumor activity in preclinical hematologic tumor models.

AZD-5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with a bivalent binding mode. AZD-5153 ligates two bromodomains in BRD4 simultaneously. Displays cellular and antitumor activity in preclinical hematologic tumor models.

B2020 | AZD-5153 DataSheet

Alternate Name/Synonyms: 4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one, 6-hydroxynaphthalene-2-carboxylic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1869912-40-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₃N₇O₃ ∙C₁₁H₈O₃

Molecular Weight: 667.8

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective, and orally available BET/BRD4 bromodomain inhibitor

MDL Number: N/A

PubChem CID: 126970641

SMILES: CC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C.C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O

InChi: InChI=1S/C25H33N7O3.C11H8O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23;12-10-4-3-7-5-9(11(13)14)2-1-8(7)6-10/h4-9,18,20H,10-17H2,1-3H3;1-6,12H,(H,13,14)

InChi Key: UNZQBHXKCHECEC-UHFFFAOYSA-N