Description
AZD-5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with a bivalent binding mode. AZD-5153 ligates two bromodomains in BRD4 simultaneously. Displays cellular and antitumor activity in preclinical hematologic tumor models.
AZD-5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with a bivalent binding mode. AZD-5153 ligates two bromodomains in BRD4 simultaneously. Displays cellular and antitumor activity in preclinical hematologic tumor models.
Alternate Name/Synonyms: 4-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl]phenoxy]ethyl]-1,3-dimethylpiperazin-2-one, 6-hydroxynaphthalene-2-carboxylic acid
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1869912-40-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₅H₃₃N₇O₃ ∙C₁₁H₈O₃
Molecular Weight: 667.8
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, selective, and orally available BET/BRD4 bromodomain inhibitor
MDL Number: N/A
PubChem CID: 126970641
SMILES: CC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C.C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O
InChi: InChI=1S/C25H33N7O3.C11H8O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23;12-10-4-3-7-5-9(11(13)14)2-1-8(7)6-10/h4-9,18,20H,10-17H2,1-3H3;1-6,12H,(H,13,14)
InChi Key: UNZQBHXKCHECEC-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |