AZD-5438 | B2073

AZD-5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC₅₀ values are 16, 6 and 20 nM for CDK1, 2, and 9, respectively). Displays antiproliferative activity in human tumor cell lines. It is less potent to CDK5/6 and also inhibits GSK3β.

AZD-5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC₅₀ values are 16, 6 and 20 nM for CDK1, 2, and 9, respectively). Displays antiproliferative activity in human tumor cell lines. It is less potent to CDK5/6 and also inhibits GSK3β.

B2073 | AZD-5438 DataSheet

Alternate Name/Synonyms: 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 602306-29-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₁N₅OS

Molecular Weight: 371.46

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of cyclin-dependent kinases (CDKs)

MDL Number: N/A

PubChem CID: 16747683

SMILES: CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C

InChi: InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)

InChi Key: WJRRGYBTGDJBFX-UHFFFAOYSA-N