Description
AZD-5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC₅₀ values are 16, 6 and 20 nM for CDK1, 2, and 9, respectively). Displays antiproliferative activity in human tumor cell lines. It is less potent to CDK5/6 and also inhibits GSK3β.
AZD-5438 is a potent inhibitor of cyclin-dependent kinases (CDKs) (IC₅₀ values are 16, 6 and 20 nM for CDK1, 2, and 9, respectively). Displays antiproliferative activity in human tumor cell lines. It is less potent to CDK5/6 and also inhibits GSK3β.
Alternate Name/Synonyms: 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine
Appearance: Off-white solid
Formulation: N/A
CAS Number: 602306-29-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₂₁N₅OS
Molecular Weight: 371.46
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent inhibitor of cyclin-dependent kinases (CDKs)
MDL Number: N/A
PubChem CID: 16747683
SMILES: CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C
InChi: InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)
InChi Key: WJRRGYBTGDJBFX-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |