AZD-6738 | B1167

AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.

AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.

B1167 | AZD-6738 DataSheet

Alternate Name/Synonyms: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine

Appearance: White Solid

Formulation: N/A

CAS Number: 1352226-88-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄N₆O₂S

Molecular Weight: 412.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: AZD6738 is an orally active and bioavailable ATR kinase inhibitor

MDL Number: N/A

PubChem CID: 121228639

SMILES: CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4

InChi: InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1

InChi Key: QCMVAPXCVDFKBD-UYKWCLKASA-N