Description
AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.
AZD6738 is a potent ATR kinase inhibitor with IC₅₀ value of 1 nM against the isolated enzyme. AZD6738 selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis. It also induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines.
Alternate Name/Synonyms: 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
Appearance: White Solid
Formulation: N/A
CAS Number: 1352226-88-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₂₄N₆O₂S
Molecular Weight: 412.51
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~0.5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: AZD6738 is an orally active and bioavailable ATR kinase inhibitor
MDL Number: N/A
PubChem CID: 121228639
SMILES: CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4
InChi: InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1
InChi Key: QCMVAPXCVDFKBD-UYKWCLKASA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |