AZD1480 | 2315

AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.

AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.

2315 | AZD1480 DataSheet

Alternate Name/Synonyms: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 935666-88-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₄H₁₄ClFN₈

Molecular Weight: 348.77

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~70 mg/ml) or Ethanol (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK1 and JAK2 inhibitor

MDL Number: MFCD16038904

PubChem CID: 16659841

SMILES: CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F

InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1

InChi Key: PDOQBOJDRPLBQU-QMMMGPOBSA-N