Description
AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.
AZD1480 is a novel ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ of 1.3 nM and 0.26 nM, respectively.
Alternate Name/Synonyms: (S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 935666-88-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₄ClFN₈
Molecular Weight: 348.77
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~70 mg/ml) or Ethanol (~ 5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent JAK1 and JAK2 inhibitor
MDL Number: MFCD16038904
PubChem CID: 16659841
SMILES: CC1=CC(=NN1)NC2=NC(=NC=C2Cl)NC(C)C3=NC=C(C=N3)F
InChi: InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1
InChi Key: PDOQBOJDRPLBQU-QMMMGPOBSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |