BACH2 Antibody (C-term) [APR07075G]

BACH2 Antibody (C-term) [APR07075G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This BACH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 815-841 amino acids from the C-terminal region of human BACH2.

Cellular Localisation: Cytoplasm. Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:17018862, ECO:0000269|PubMed:28530713}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation.

Molecular Weight: 92537

Clone: Polyclonal

Gene Name: BACH2

Gene ID: 60468

Function: Transcriptional regulator that acts as repressor or activator (By similarity) . Binds to Maf recognition elements (MARE) (By similarity) . Plays an important role in coordinating transcription activation and repression by MAFK (By similarity) . Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862) . Positively regulates the nuclear import of actin (By similarity) . Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713) .

Summary: Tissue Location: B-cell specific.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Transcription regulator protein BACH2, BTB and CNC homolog 2, BACH2