BAG 956 | 2456

A potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively). Displays anticancer properties.

BAG 956 is a potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively).

2456 | BAG 956 DataSheet

Alternate Name/Synonyms: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyr​idinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-be​nzeneacetonitrile

Appearance: Red solid

Formulation: N/A

CAS Number: 853910-02-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₁N₅

Molecular Weight: 427.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml) or EtOH (~7 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A dual PI3K/PDK-1 inhibitor

MDL Number: N/A

PubChem CID: 24882589

SMILES: CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5

InChi: InChI=1S/C28H21N5/c1-19-32-26-17-31-25-13-8-20(6-7-21-5-4-14-30-16-21)15-24(25)27(26)33(19)23-11-9-22(10-12-23)28(2,3)18-29/h4-5,8-17H,1-3H3

InChi Key: GVPAGJWVBUZHNQ-UHFFFAOYSA-N