Description
A potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively). Displays anticancer properties.
BAG 956 is a potent, ATP-competitive, dual PI3K/PDK-1 inhibitor in vitro and in vivo (IC₅₀ = 56, 444, 34, 117 and 240 nM for PI3K p110-α ,β,d, γ, and PDK1 kinases, respectively).
Alternate Name/Synonyms: α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
Appearance: Red solid
Formulation: N/A
CAS Number: 853910-02-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₈H₂₁N₅
Molecular Weight: 427.5
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~15 mg/ml) or EtOH (~7 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A dual PI3K/PDK-1 inhibitor
MDL Number: N/A
PubChem CID: 24882589
SMILES: CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5
InChi: InChI=1S/C28H21N5/c1-19-32-26-17-31-25-13-8-20(6-7-21-5-4-14-30-16-21)15-24(25)27(26)33(19)23-11-9-22(10-12-23)28(2,3)18-29/h4-5,8-17H,1-3H3
InChi Key: GVPAGJWVBUZHNQ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |