Description
Bardoxolone is a synthetic oleanane triterpenoid that inhibits cellular iNOS production when stimulated by IFNg, TNF-α and IL-1. It is Reata’s investigational lead molecule for CKD (chronic kidney disease). It is a potent inducer of the transcription factor Nrf2 which is an important biological target that controls the production of many of the body’s antioxidant and detoxification enzymes.
Bardoxolone is a synthetic oleanane triterpenoid that inhibits cellular iNOS production when stimulated by IFNg, TNF-α and IL-1. It is Reata’s investigational lead molecule for CKD (chronic kidney disease). It is a potent inducer of the transcription factor Nrf2 which is an important biological target that controls the production of many of the body’s antioxidant and detoxification enzymes.
Alternate Name/Synonyms: 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid; RTA 402; CDDO
Appearance: Light brown Solid
Formulation: N/A
CAS Number: 218600-44-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₁H₄₁NO₄
Molecular Weight: 491.66
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>4.5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An iNOS inhibitor
MDL Number: N/A
PubChem CID: 400010
SMILES: CC1(CCC2(CCC3(C(C2C1)C(=O)C=C4C3(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)C)C(=O)O)C
InChi: 1S/C31H41NO4/c1-26(2)10-12-31(25(35)36)13-11-30(7)23(19(31)16-26)20(33)14-22-28(5)15-18(17-32)24(34)27(3,4)21(28)8-9-29(22,30)6/h14-15,19,21,23H,8-13,16H2,1-7H3,(H,35,36)/t19-,21-,23-,28-,29+,30+,31-/m0/s1
InChi Key: TXGZJQLMVSIZEI-UQMAOPSPSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
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