BAX Activator, BAM7 | 2451

A potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins. BAM7 triggers in vitro BAX oligomerization, BAX-mediated pore formation and BAX-dependent cell death. BAM7 selectively induces BAX-mediated apoptosis by triggering the hallmark features of intracellular BAX activation. BAM7 only kills the cell line that contains BAX, eliciting the biochemical and morphologic features of BAX-mediated apoptosis.

BAM7 is a potent and selective BAX activator (EC₅₀ = 3.3 μM). BAM7 directly binds at the BH3-binding site; selective for BAX over other antiapoptotic and proapoptotic proteins.

2451 | BAX Activator, BAM7 DataSheet

Alternate Name/Synonyms: 3-Methyl-1-(4-phenyl-2-thiazolyl)-1​H-pyrazole-4,5-dione 4-[2-(2-Ethoxyphenyl)hydrazone]; BAM7

Appearance: Brown solid

Formulation: N/A

CAS Number: 331244-89-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₉N₅O₂S

Molecular Weight: 405.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities:

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective BAX activator

MDL Number: N/A

PubChem CID: 5754137

SMILES: CCOC1=CC=CC=C1NN=C2C(=NN(C2=O)C3=NC(=CS3)C4=CC=CC=C4)C

InChi: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+

InChi Key: KOCVKGYKBLJEPK-LYBHJNIJSA-N