Description
Bax Antibody [2D2] | 99-622 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human, Monkey, Dog, Bovine
Homology: N/A
Immunogen: Human Bax peptide (a.a. 3-16)
Research Area: Membrane, Cell Cycle, Cancer, Apoptosis
Tested Application: Flow
Application: Bax Antibody [2D2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, purification, and neutralization assays.
Specificiy: Bax
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: N/A
Clonality: Monoclonal
Clone: [2D2]
Isotype: IgG1
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration: 0.1 mg/mL
Storage Condition: Store vial at 2-8˚C
Alternate Name: Apoptosis regulator BAX, BCL2 associated X protein
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Bax is a 20-22 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. In murine thymocytes, it is expressed primarily as a cytoplasmic protein. Over-expression of Bax promotes apoptosis by formation of homodimers and through heterodimerization with Bcl-2, an inhibitor of apoptosis. The monoclonal antibody 2D2 reacts with an N-terminal epitope between amino acids 3-16 of human Bax. It can bind both soluble and detergent-altered forms of Bax as well as Bax-Bcl-2 and Bax-Bcl-xL heterodimers.