BAY-1895344 hydrochloride | B1962

BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

B1962 | BAY-1895344 hydrochloride DataSheet

Alternate Name/Synonyms: (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1876467-74-1 (free base)

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂ClN₇O

Molecular Weight: 411.89

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor

MDL Number: N/A

PubChem CID: 118869362

SMILES: CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C

InChi: InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1

InChi Key: YBXRSCXGRPSTMW-CYBMUJFWSA-N