BAY 43-9006 (Tosylate) | 1594

BAY 43-9006 (Sorafenib) is an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).

BAY 43-9006 (Sorafenib) is an inhibitor of Raf-1 and B-Raf (IC₅₀ = 6 and 22 nM, respectively), as well as several receptor tyrosine kinases, including VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC₅₀ = 90, 15, 20, 57, and 58 nM, respectively. It poorly inhibits ERK1, MEK1, and several other kinases (IC₅₀ = >10 μM).

1594 | BAY 43-9006 (Tosylate) DataSheet

Alternate Name/Synonyms:

Appearance: Off-white solid

Formulation: N/A

CAS Number: 475207-59-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₆ClF₃N₄O₃.C₇H₈O₃S

Molecular Weight: 637.03

Cell-Permeable?: Yes

Purity: ≥99%

Solubilities: DMSO (200 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A Raf kinase inhibitor

MDL Number: MFCD08235032

PubChem CID: 406563

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

InChi: InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5- 2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23, 24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H, 1H3,(H,8,9,10)

InChi Key: IVDHYUQIDRJSTI-UHFFFAOYSA-N