26
Bay 61-3606 Hydrochloride | 1796
- SKU:
- 26-1796-GEN
- Availability:
- Usually shipped in 5 working days
Description
Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.
Bay 61-3606 is a potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.
1796 | Bay 61-3606 Hydrochloride DataSheet
Alternate Name/Synonyms: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
Appearance: Yellow solid
Formulation: N/A
CAS Number: 732983-37-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₀H₁₈N₆O₃.HCl
Molecular Weight: 426.86
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: H₂O (30 mg/ml) DMSO (2 mg/ml)
Handling: Protect from light and moisture
Country of Origin: USA
Tag Line: A Syk inhibitor
MDL Number: N/A
PubChem CID: 52949496
SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl
InChi: InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
InChi Key: HLYFDKZWVIBYKL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
48 months |