Bay 61-3606 Hydrochloride | 1796

Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.

Bay 61-3606 is a potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC₅₀ = 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 µM. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.

1796 | Bay 61-3606 Hydrochloride DataSheet

Alternate Name/Synonyms: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl

Appearance: Yellow solid

Formulation: N/A

CAS Number: 732983-37-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₈N₆O₃.HCl

Molecular Weight: 426.86

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: H₂O (30 mg/ml) DMSO (2 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A Syk inhibitor

MDL Number: N/A

PubChem CID: 52949496

SMILES: COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl

InChi: InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H

InChi Key: HLYFDKZWVIBYKL-UHFFFAOYSA-N