BAY-677 | B3060

BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE with IC₅₀>2000 nM.

BAY-677 is a negative control for BAY-678. BAY-678 is a potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 20 nM. The S-enantiomer BAY-677 inhibits HNE with IC₅₀>2000 nM.

B3060 | BAY-677 DataSheet

Alternate Name/Synonyms: 5-[(6S)-5-acetyl-4-methyl-2-oxo-3-[3-(trifluoromethyl)phenyl]-1,6-dihydropyrimidin-6-yl]pyridine-2-carbonitrile; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile

Appearance: Yellow solid

Formulation:

CAS Number: 2117404-84-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₀H₁₅F₃N₄O₂

Molecular Weight: 400.35

Cell-Permeable?: TRUE

Purity: ≥97%

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A negative control for BAY-678

MDL Number: MFCD30146413

PubChem CID: 68944900

SMILES: CC1=C(C(NC(=O)N1C2=CC=CC(=C2)C(F)(F)F)C3=CN=C(C=C3)C#N)C(=O)C

InChi: InChI=1S/C20H15F3N4O2/c1-11-17(12(2)28)18(13-6-7-15(9-24)25-10-13)26-19(29)27(11)16-5-3-4-14(8-16)20(21,22)23/h3-8,10,18H,1-2H3,(H,26,29)/t18-/m0/s1

InChi Key: PGIVGIFOWOVINL-SFHVURJKSA-N