Description
BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative of the PAD inhibitor Cl-amidine in which the C-terminal carboxamide is replaced with a benzimidazole moiety to reduce proteolysis. The cellular potency of BB-Cl-amidine is 20-fold higher than Cl-amidine. The EC₅₀ value for inhibition of viability of U2OS osteosarcoma cells is 8.8 μM. It improves endothelium-dependent vasorelaxation in MRL/lpr mice. It inhibits the formation of neutrophil extracellular traps without altering H₂O₂ production by neutrophils.
BB-Cl-Amidine is a pan-peptidylarginine deiminase (PAD) inhibitor. Peptidylarginine deiminase catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline. BB-Cl-Amidine is a derivative of the PAD inhibitor Cl-amidine in which the C-terminal carboxamide is replaced with a benzimidazole moiety to reduce proteolysis. The cellular potency of BB-Cl-amidine is 20-fold higher than Cl-amidine. The EC₅₀ value for inhibition of viability of U2OS osteosarcoma cells is 8.8 μM. It improves endothelium-dependent vasorelaxation in MRL/lpr mice. It inhibits the formation of neutrophil extracellular traps without altering H₂O₂ production by neutrophils.
B2847 | BB-Cl-Amidine DataSheet
Alternate Name/Synonyms: N-[4-[(1-amino-2-chloroethylidene)amino]-1-(1H-benzimidazol-2-yl)butyl]-4-phenylbenzamide; N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-[1,1'-biphenyl]-4-carboxamide
Appearance: A crystalline solid
Formulation:
CAS Number: 1802637-39-3
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₂₆H₂₆ClN₅O
Molecular Weight: 459.97
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~25 mg/ml in in Ethanol, ~20 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A pan-peptidylarginine deiminase (PAD) inhibitor
MDL Number:
PubChem CID: 134580850
SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC(CCCN=C(CCl)N)C3=NC4=CC=CC=C4N3
InChi: InChI=1S/C26H26ClN5O/c27-17-24(28)29-16-6-11-23(25-30-21-9-4-5-10-22(21)31-25)32-26(33)20-14-12-19(13-15-20)18-7-2-1-3-8-18/h1-5,7-10,12-15,23H,6,11,16-17H2,(H2,28,29)(H,30,31)(H,32,33)
InChi Key: YDOAWJHYHGBQFI-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |