Bcr (S356) polyclonal Antibody | BS1513

Bcr (S356) polyclonal Antibody | BS1513 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c-Abl proto-oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90-95% of patients with chronic myelogenous leukemia (CML) . The Bcr gene encodes for the Breakpoint cluster region protein (Bcr) . A consequence of this translocation is the generation of a Bcr/c-Abl mRNA encoding an activated c-Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Bcr (S356) polyclonal Antibody detects endogenous levels of Bcr protein.

Molecular Weight: ~ 160 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Breakpoint cluster region protein; Renal carcinoma antigen NY-REN-26; BCR; BCR1; D22S11

Immunogen: Synthetic peptide, corresponding to amino acids 321-370 of Human Bcr.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: MAPK Erk in Growth and Differentiation Pathway,