Beauvericin | B1246

Beauvercin is an enniatin mycotoxin isolated from fungus Beauveria sp. It has shown cytotoxic properties against insect cells SF-9 and induces apoptosis with IC₅₀ value of 4.5 µM. It has shown to affect mitochondria by depleting the transmembrane potential, inducing swelling and decreasing calcium retention capacity.

Beauvercin is an enniatin mycotoxin isolated from fungus Beauveria sp. It has shown cytotoxic properties against insect cells SF-9 and induces apoptosis with IC₅₀ value of 4.5 µM. It has shown to affect mitochondria by depleting the transmembrane potential, inducing swelling and decreasing calcium retention capacity.

B1246 | Beauvericin DataSheet

Alternate Name/Synonyms: Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-phenylalanyl]

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 26048-05-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₅H₅₇N₃O₉

Molecular Weight: 783.96

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO(>19 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An enniatin mycotoxin inducing apoptosis and having cytotoxic properties

MDL Number: MFCD00056846

PubChem CID: 105014

SMILES: CC(C)C1C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)O1)CC2=CC=CC=C2)C)C(C)C)CC3=CC=CC=C3)C)C(C)C)CC4=CC=CC=C4)C

InChi: InChI=1S/C45H57N3O9/c1-28(2)37-40(49)46(7)35(26-32-21-15-11-16-22-32)44(53)56-39(30(5)6)42(51)48(9)36(27-33-23-17-12-18-24-33)45(54)57-38(29(3)4)41(50)47(8)34(43(52)55-37)25-31-19-13-10-14-20-31/h10-24,28-30,34-39H,25-27H2,1-9H3

InChi Key: GYSCAQFHASJXRS-UHFFFAOYSA-N