Beclin Antibody| F46280-0.4ML

Beclin Antibody| F46280-0.4ML | Gentaur UK, US & Europe Distribution

Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Beclin 1 plays a role in two fundamentally important cell biological pathways: autophagy and apoptosis. Beclin 1 is thought to function as a VPS and autophagy protein as part of a complex with Class III PI3 kinase, Vps34.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Bovine, Pig, Rat

Application: FACS, WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50

Application Note: Titration of the Beclin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Beclin antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 210-239 from the human protein was used as the immunogen for this Beclin antibody.

Storage: Aliquot the Beclin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A