LBD
BEND3 Antibody (C-term) [APR31432G]
- SKU:
- LBD-APR31432G
- Availability:
- Usually ships in 5 working days
Description
BEND3 Antibody (C-term) [APR31432G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This BEND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 629-657 amino acids from the C-terminal region of human BEND3.
Cellular Localisation: Nucleus. Nucleus, nucleolus. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation.
Molecular Weight: 94475
Clone: Polyclonal
Gene Name: BEND3
Gene ID: 57673
Function: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909) . Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity) . Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671) .
Summary: Tissue Location: Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart Expressed on the surface of T-cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: BEN domain-containing protein 3, BEND3, KIAA1553