Bendamustine Hydrochloride | B1596

Bendamustine is a novel alkylating agent with a benzimidazole ring giving it purine analogue-like properties. Like other alkylating agents, bendamustine is thought to act by modifying and cross linking purine bases in DNA, thus inhibiting DNA, RNA and protein synthesis and leading to cell death in rapidly dividing cells. Bendamustine appears to have a special activity against B cell leukemias and lymphomas.

Bendamustine is a novel alkylating agent with a benzimidazole ring giving it purine analogue-like properties. Like other alkylating agents, bendamustine is thought to act by modifying and cross linking purine bases in DNA, thus inhibiting DNA, RNA and protein synthesis and leading to cell death in rapidly dividing cells. Bendamustine appears to have a special activity against B cell leukemias and lymphomas.

B1596 | Bendamustine Hydrochloride DataSheet

Alternate Name/Synonyms: 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 3543-75-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₆H₂₁Cl₂N₃O₂.HCl

Molecular Weight: 394.71

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>30 mg/ml) or EtOH (>20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An anticancer agent

MDL Number: MFCD16879055

PubChem CID: 77082

SMILES: CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl

InChi: InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H

InChi Key: ZHSKUOZOLHMKEA-UHFFFAOYSA-N