Beta-Secretase Inhibitor II | 7502

A potent, cell permeable and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC₅₀ = 700 nM) and Aβ1-42 (IC₅₀ = 2.5 µM) in CHO cells stably transfected with wild-type APP751.

7502 | Beta-Secretase Inhibitor II DataSheet

Alternate Name/Synonyms:

Appearance: White solid

Formulation: N/A

CAS Number: N/A

Structure Available?: No

Peptide sequence: Z-Val-Leu-Leu--CHO

Salt Form: No

Molecular Formula: C₂₅H₃₉N₃O₅

Molecular Weight: 461.6

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A beta-secretase inhibitor

MDL Number: N/A

PubChem CID: 10253763

SMILES: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1

InChi: 239-200(315)150(93-258)251-190(305)143(82-112-90-215-95-219-112)248-203

InChi Key: YHUAFMGVVANYBT-FKBYEOEOSA-N