BI 6727 | 2222

A highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1, 2 and 3 (PLK1, 2 and 3), with IC₅₀s at 0.87, 5 and 56 nM, respectively.

BI 6727 is a highly potent, selective and ATP-competitive inhibitor of polo-like kinases 1, 2 and 3 (PLK1, 2 and 3), with IC₅₀s at 0.87, 5 and 56 nM, respectively.

2222 | BI 6727 DataSheet

Alternate Name/Synonyms: Volasertib

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 755038-65-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₄H₅₀N₈O₃

Molecular Weight: 618.81

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A polo-like kinase (PLK) inhibitor

MDL Number: MFCD20926414

PubChem CID: 10461508

SMILES: CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

InChi: InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25?,26?,28-/m1/s1

InChi Key: SXNJFOWDRLKDSF-XKHVUIRMSA-N