BI-9564 | B1880

BI-9564 is a potent, selective and cell-permeable BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Displays selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo.

BI-9564 is a potent, selective and cell-permeable BRD9 and BRD7 inhibitor (Kd values are 14 and 239 nM, respectively). Displays selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo.

B1880 | BI-9564 DataSheet

Alternate Name/Synonyms: 4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1883429-22-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₃N₃O₃

Molecular Weight: 353.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, selective and cell-permeable BRD9 and BRD7 inhibitor

MDL Number: N/A

PubChem CID: 117072549

SMILES: CN1C=C(C2=C(C1=O)C=NC=C2)C3=CC(=C(C=C3OC)CN(C)C)OC

InChi: InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3

InChi Key: BJFSUDWKXGMUKA-UHFFFAOYSA-N