BIO | 1673

A potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.

BIO is a potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Under a feeder-free condition, BIO maintains embryonic stem cells (hESCs) in the undifferentiated state.

1673 | BIO DataSheet

Alternate Name/Synonyms: (2Z, 3E)-6’-Bromo-3-(hydroxyimino)-[2,3’-biindolinylidene]-2’-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 667463-62-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₀BrN₃O₂

Molecular Weight: 356.17

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (10 mg/ml) or EtOH (0.5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A GSK-3 inhibitor

MDL Number: MFCD08705318

PubChem CID: 5287844

SMILES: C1=CC2=C(C(=C3C4=C(C=C(C=C4)Br)NC3=O)N=C2C=C1)NO

InChi: InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13-

InChi Key: WNWSUJQVZJJGLF-SQFISAMPSA-N