BIX02189 | 2670

BIX02189 is a potent MEK5 inhibitor (IC₅₀ = 1.5 nM). Also inhibits ERK5 catalytic activity (IC₅₀ = 59 nM). Does not inhibit closely related kinases MEK1, MEK2, ERK2 and JNK2.

BIX02189 is a potent MEK5 inhibitor (IC₅₀ = 1.5 nM). Also inhibits ERK5 catalytic activity (IC₅₀ = 59 nM). Does not inhibit closely related kinases MEK1, MEK2, ERK2 and JNK2.

2670 | BIX02189 DataSheet

Alternate Name/Synonyms: (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1094614-85-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₈N₄O₂

Molecular Weight: 440.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent MEK5 inhibitor

MDL Number: N/A

PubChem CID: 46931012

SMILES: CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)C4=CC=CC=C4

InChi: InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24-

InChi Key: HOMJAAIVTDVQJA-IZHYLOQSSA-N