BLK (phospho-Y389) polyclonal Antibody | BS64159

BLK (phospho-Y389) polyclonal Antibody | BS64159 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development. Activation of B cells by various ligands is accompanied by activation of Blk. It has been suggested that Blk is involved in the control of B cell differentiation and proliferation. Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis. Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BLK (phospho-Y389) polyclonal Antibody detects endogenous levels of BLK protein only when phosphorylated at Tyr389 .

Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Tyrosine-protein kinase Blk; B lymphocyte kinase; p55-Blk; BLK

Immunogen: Synthetic phosphopeptide derived from human BLK around the phosphorylation site of Tyrosine389.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Hypoxia Signaling,Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT,Contribution of Soluble Factors to EMT,hippo Signaling,Adherens Junction signaling,